abstract：:Recent developments in intrabronchial administration of insulin raise lung function in patients with type I diabetes as important issue. Several studies in adults report abnormalities of lung function of these patients. The aim of this study was to investigate lung function in children with type I diabetes. Twenty-sev...

journal_title：Respiratory medicine

authors： van Gent R,Brackel HJ,de Vroede M,van der Ent CK

更新日期：2002-12-01 00:00:00

abstract：:We studied tuberculin reactivity in young Norwegian adults and its possible dependency on age, gender, previous BCG vaccination, smoking habits, occupational exposure, diet as well as years of education as a measure of socio-economic status. Responders of a random sample of men and women aged 20-44 years living in Ber...

journal_title：Respiratory medicine

authors： Jentoft HF,Omenaas E,Eide GE,Gulsvik A

更新日期：2002-12-01 00:00:00

abstract：:Induced sputum and bronchoalveolar lavage (BAL) are widely used for retrieving cells and soluble materials for studies of airway inflammation. Centrifuged cell samples are suitable for immunochemical identification of cellular products. The aim was to determine the optimal fixation procedure to detect intracellular an...

journal_title：Respiratory medicine

authors： Metso T,Haahtela T,Sevéus L

更新日期：2002-11-01 00:00:00

abstract：STUDY OBJECTIVES:Penicillin resistance has been reported in various studies to have no impact on the outcome of pneumococcal pneumonia. However, the importance of cephalosporin resistance has not been systematically studied. We conducted an analysis of patients with high-level cephalosporin-resistant Streptococcus pneu...

journal_title：Respiratory medicine

authors： Ailani RK,Alimchandani A,Hidalgo J,Ailani R,Buckley J,DiGiovine B

更新日期：2002-10-01 00:00:00

abstract：:We have proposed a clinical treatment guideline for the management of acute, severe asthma and chronic obstructive pulmonarydisease (COPD) using the principles of evidence-based medicine. The content is based upon practical clinical issues in need of consensus. A previous study has shown that this particular area is i...

journal_title：Respiratory medicine

authors： Phanareth K,Hansen LS,Christensen LK,Laursen LC

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Patients with upper and lower airway symptoms and with pronounced sensitivity to chemical odours, such as perfumes, flower scents and tobacco smoke, have been suggested to have sensory hyperreactivity (SHR). The symptoms have been difficult to identify with physiological measurements and the effects of vario...

journal_title：Respiratory medicine

authors： Johansson A,Löwhagen O,Millqvist E,Bende M

更新日期：2002-09-01 00:00:00

abstract：:Weight loss has been recognized as a feature of advanced emphysema and a factor of poor prognosis, but its mechanisms remain obscure. Studies have demonstrated high serum concentrations of TNF-a (cachexin) in chronic obstructive pulmonary disease (COPD) patients with emphysema. Pink puffers (PP) COPD patients have wor...

journal_title：Respiratory medicine

authors： Pitsiou G,Kyriazis G,Hatzizisi O,Argyropoulou P,Mavrofridis E,Patakas D

更新日期：2002-08-01 00:00:00

abstract：:Healthcare payers are faced with the need to allocate finite resources to maximize population health. To assist in decision-making, healthcare payers are increasingly using health outcomes information and economic analyses. Healthcare payers are often under pressure to make early decisions (around the time of product ...

journal_title：Respiratory medicine

authors： Levine M,Taylor R,Ryan M,Sculpher M

更新日期：2002-08-01 00:00:00

abstract：:In the drive to replace chlorofluorinated hydrocarbons (CFCs) by alternative more environmentally friendly propellants in pressurized metered dose inhalers (pMDIs), Chiesi has developed new inhalers using Modulite technology. The aim was to obtain CFC-free pMDIs which are equivalent, in terms of safety and efficacy, t...

journal_title：Respiratory medicine

authors： Woodcock A,Acerbi D,Poli G

更新日期：2002-08-01 00:00:00

abstract：:This retrospective study was designed to evaluate the safety and efficacy of a bronchoprotective sputum induction protocol in moderate to severe chronic obstructive pulmonary disease (COPD). Forty-two adults with COPD (FEV1 = 51.7 +/- 3.2% predicted (mean +/- SEM)) under went sputum induction using a protocol designed...

journal_title：Respiratory medicine

authors： Sutherland ER,Pak J,Langmack EL,Silkoff PE,Martin RJ

更新日期：2002-07-01 00:00:00

abstract：:The sputum smear-negative patients have been a diagnostic challenge for health professionals. Adenosine deaminase (ADA) activity has been shown to rise in various body fluids of patients with tuberculosis (Tb). A prospective clinical trial was conducted to determine the diagnostic value of ADA activity in bronchoalveo...

journal_title：Respiratory medicine

authors： Kayacan O,Karnak D,Delibalta M,Beder S,Karaca L,Tutkak H

更新日期：2002-07-01 00:00:00

abstract：:A double-blind, randomized crossover study in 28 asthmatic patients assessed the relative therapeutic index for inhaled formoterol and salbutamol. Pre-drug administration FEV1 (mean 2.08 l) was 49-93% of predicted and reversibility 16-82% after inhalation of salbutamol. Patients inhaled single doses of formoterol (Oxi...

journal_title：Respiratory medicine

authors： Rosenborg J,Larsson R,Rott Z,Böcskei C,Poczi M,Juhász G

更新日期：2002-06-01 00:00:00

abstract：:To answer the question as to whether pulmonary rehabilitation programs (PRP) induced increase in exercise tolerance (ET) is associated with increased levels of exhaled nitric oxide (eNO) in COPD patients of different degrees of severity, we designed a prospective and controlled study. Forty-seven stable COPD patients ...

journal_title：Respiratory medicine

authors： Clini E,Bianchi L,Foglio K,Vitacca M,Ambrosino N

更新日期：2002-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common and highly contagious pathogen that infects nearly all children by the age of 2 years. It is responsible for significant morbidity and mortality worldwide among certain high-risk paediatric populations. Therapy is sub-optimal for RSV, thus treatment focuses on ameliorating...

journal_title：Respiratory medicine

authors： Simoes EA,Groothuis JR

更新日期：2002-04-01 00:00:00

abstract：:The purpose of this randomized, double-blind parallel group study was to compare the safety, tolerability and acceptability of Easyhaler and Turbuhaler dry powder inhalers for the delivery of budesonide 800 microg day(-1) in adult asthmatic patients who had already been treated with inhaled corticosteroids for at leas...

journal_title：Respiratory medicine

authors： Tukiainen H,Rytilä P,Hämäläinen KM,Silvasti MS,Keski-Karhu J,Finnish Study Group.

更新日期：2002-04-01 00:00:00

abstract：:Asthma and wheezing illnesses carry a significant burden of disease during childhood. Prevalence studies have the capacity to provide invaluable insights into the nature of these common conditions. As part of the Isle of Wight Whole Population Birth Cohort Study (n=1456) we have examined wheezing and asthma developmen...

journal_title：Respiratory medicine

authors： Kurukulaaratchy RJ,Fenn M,Twiselton R,Matthews S,Arshad SH

更新日期：2002-03-01 00:00:00

abstract：:Asthma has become an important public health issue worldwide and certain groups, such as children, are at particular risk of the disease. Often asthma remains under-diagnosed and under-treated. Despite these worrying trends, the disease management approach to asthma control can help most asthma patients achieve a 'nor...

journal_title：Respiratory medicine

authors： Haahtela T

更新日期：2002-02-01 00:00:00

abstract：:Prolonged cough is a common problem in patients seen in general practice. Using a simple method of sputum induction and processing of sputum samples, we determined whether eosinophilic airway inflammation could be a cause of undiagnosed prolonged cough. Eighty-two patients who had had cough for more than 1 month were ...

journal_title：Respiratory medicine

authors： Rytilä P,Metso T,Petäys T,Sohlman A,Työlahti H,Kohonen-Jalonen P,Kiviniemi P,Haahtela T

更新日期：2002-01-01 00:00:00

abstract：:Exposure to mushroom spores may cause many respiratory allergic diseases, however, there has been no serial study in a mushroom factory to address this problem. The aim of this study was to investigate the serial changes in respiratory allergy and the incidence of hypersensitivity pneumonitis (HP) in mushroom workers....

journal_title：Respiratory medicine

authors： Tanaka H,Saikai T,Sugawara H,Tsunematsu K,Takeya I,Koba H,Matsuura A,Imai K,Abe S

更新日期：2001-12-01 00:00:00

abstract：:Lactose is widely used as a carrier of drugs in inhalation devices for asthmatic patients, but some clinicans have suspected that it may cause bronchoconstriction. Only a few studies have been done to examine this and the results are not uniform. This study was conducted to determine the effects of inhalation grade la...

journal_title：Respiratory medicine

authors： Thoren P,Wallin A,Whitehead PJ,Sandström T

更新日期：2001-11-01 00:00:00

abstract：:The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with chemoimmunotherapy wh...

journal_title：Respiratory medicine

authors： Metintas M,Metintas S,Ucgun I,Gibbs AR,Harmanci E,Alatas F,Erginel S,Tel N,Pasaoglu O

更新日期：2001-10-01 00:00:00

abstract：:The aim of this study was to examine an acoustic reflection method using a flexible tube for identifying the obstructive site of the upper airway in snorers and patients with obstructive sleep apnoea (OSA). As a preliminary study it was performed n models and subjects in the awake state. Flextube narrowing was produce...

journal_title：Respiratory medicine

authors： Faber CE,Grymer L,Norregaard O,Hilberg O

更新日期：2001-08-01 00:00:00

abstract：:Current asthma management guidelines state that where a patient is receiving a low to moderate dose of inhaled corticosteroids and is still experiencing symptoms the dose of corticosteroid should be increased and, if necessary, a long-acting bronchodilator should be added. Many studies have now shown that the addition...

journal_title：Respiratory medicine

authors： Barnes PJ

更新日期：2001-08-01 00:00:00

abstract：:Haemoptysis is an alarming symptom, and the management depends upon the aetiology. Emergency management depends upon localization of the site of bleeding by roentgenogram, computerized chest tompgraphy and bronchoscopy. We prospectively evaluated 52 patients with haemoptysis admitted to the Chest Hospital, Kuwait for ...

journal_title：Respiratory medicine

authors： Abal AT,Nair PC,Cherian J

更新日期：2001-07-01 00:00:00

abstract：:The objective of this study was to compare surfactant (SF) distribution and physiological effects after standard SF delivery during conventional mechanical ventilation (CMV) with that using partial liquid ventilation (PLV). A model of meconium aspiration syndrome (MAS) was developed using two groups of adult rats (n =...

journal_title：Respiratory medicine

authors： Chappell SE,Wolfson MR,Shaffer TH

更新日期：2001-07-01 00:00:00

abstract：:The ability of immunotherapy with heat-killed Mycobacterium vaccae (NCTC 11659), as an addition to the available chemotherapy, to improve the outcome in patients with multi-drug-resistant tubercle bacilli (MDRTB) who had not been cured by chemotherapy alone was evaluated in tuberculosis centres in Estonia, Iran, Kuwai...

journal_title：Respiratory medicine

authors： Stanford JL,Stanford CA,Grange JM,Lan NN,Etemadi A

更新日期：2001-06-01 00:00:00

abstract：:This research was carried out to develop a new carrier in dry powder aerosols. Two types of cyclodextrin were chosen; gamma cyclodextrin (GCD) and dimethyl-beta-cyclodextrin (DMCD) as carriers in dry powder formulations. Salbutamol was used as a model drug and a control formulation containing lactose and the drug was ...

journal_title：Respiratory medicine

authors： Srichana T,Suedee R,Reanmongkol W

更新日期：2001-06-01 00:00:00

abstract：:Collection of airway calibre and beta2-agonist data in large clinical trials and epidemiological surveys is sometimes difficult and may be an inefficient use of resources. The aim of this study was to determine whether the omission of the forced expiratory volume in 1 sec (FEV1) and beta2-agonist questions from the se...

journal_title：Respiratory medicine

authors： Juniper EF,O'Byrne PM,Roberts JN

更新日期：2001-05-01 00:00:00

abstract：:The aim of the study was to investigate which features predict favourable response to omeprazole therapy in asthmatics with gastro-oesophageal reflux (GER). The study population consisted of 52 outpatient asthmatics with GER who had completed an intervention where they were randomized to receive omeprazole 40 mg once ...

journal_title：Respiratory medicine

authors： Kiljander T,Salomaa ER,Hietanen E,Helenius H,Liippo K,Terho EO

更新日期：2001-05-01 00:00:00

abstract：:Seventy-seven patients with morbid obesity, body mass index (BMI) 40-69.9 kg m(-2), who were candidates for gastroplasty, were studied in our laboratory as part of a pre-operative survey. They had no complaints other than obesity and were not cyanotic. A group of 28 lean subjects (BMI 20-29.8 kg m(-2)) who were candid...

journal_title：Respiratory medicine

authors： Ladosky W,Botelho MA,Albuquerque JP Jr

更新日期：2001-04-01 00:00:00

abstract：:Integrins play key roles in cell-to-cell and cell-to-extracellular matrix (ECM) adhesion. We investigated integrin expression on pleural mesothelial cells (PMCs) and the inhibitory effect of arginine-glycine-asparate (RGD)-containing peptide on the adhesion of PMCs to fibronectin and collagen. Using flow cytometry and...

journal_title：Respiratory medicine

authors： Liaw YS,Yu CJ,Shun CT,Lee YC,Kuo SH,Luh KT,Yang PC

更新日期：2001-03-01 00:00:00

abstract：:This multi-centre, randomized, double-blind, double-dummy, parallel-group study was designed to investigate the hypothesis of equivalent efficacy and comparable safety of two inhaled presentations of salmeterol/fluticasone propionate combination product (SALM/FP) 50/100 microg administered twice daily to patients with...

journal_title：Respiratory medicine

authors： Bateman ED,Silins V,Bogolubov M

更新日期：2001-02-01 00:00:00

abstract：:The 72 kDa matrix metalloproteinase (MMP-2) and the 92 kDa matrix metalloproteinase (MMP-9), are type IV collagenases that have been implicated as important factors in cancer invasion and metastasis formation. We have used quantitative zymography and computer-assisted image analysis to measure the levels of MMP-9 and ...

journal_title：Respiratory medicine

authors： Hrabec E,Strek M,Nowak D,Hrabec Z

更新日期：2001-01-01 00:00:00

abstract：:Inhalation of on-demand salbutamol (ODS) several times daily is sometimes the only beta2-agonist prescribed in moderate persistent asthma, whereas a long-acting beta2-agonist should be added. This trial aimed to compare the efficacy of formoterol dry-powder capsule 12 microg b.i.d. (Foradil) and ODS in patients with m...

journal_title：Respiratory medicine

authors： Molimard M,Bourcereau J,Le Gros V,Bourdeix I,Leynadier F,Duroux P,French FOR-F-01 Study Group.

更新日期：2001-01-01 00:00:00

abstract：:Totally implantable venous intravenous access devices (TIVADs) have an essential role in the frequent delivery of antibiotics in cystic fibrosis (CF) patients. This study at the Royal Brompton Hospital (RBH) reports the experience of TIVADs in patients attending the RBH adult CF unit implanted at the RBH and elsewhere...

journal_title：Respiratory medicine

authors： Kariyawasam HH,Pepper JR,Hodson ME,Geddes DM

更新日期：2000-12-01 00:00:00

abstract：:The fine particle dose delivered via dry powder inhalers (DPIs) is often affected by the inspiratory flow rate generated during inhalation. This has clinical implications, since the fine particle dose determines the amount of drug reaching the lungs. With Easyhaler DPI the fine particle dose remains relatively constan...

journal_title：Respiratory medicine

authors： Koskela T,Malmström K,Sairanen U,Peltola S,Keski-Karhu J,Silvasti M

更新日期：2000-12-01 00:00:00

abstract：:The objective of this study was to describe asthma exacerbation self-management in children and adolescents. We used a cross-sectional study population enrolled in the International Study of Asthma and Allergies in Childhood (ISAAC) in Bordeaux. Subjects answered an additional questionnaire on utilization of health se...

journal_title：Respiratory medicine

authors： Raherison C,Tunon-de-Lara JM,Vernejoux JM,Taytard A

更新日期：2000-11-01 00:00:00

abstract：:The increasing prevalence of allergic sensitization to indoor allergens such as dust mites, pets and cockroaches is the result of the changes in indoor environments induced by human activities. The Westernized lifestyle and the increasing time spent indoors determine a reduction in natural air ventilation and, consequ...

journal_title：Respiratory medicine

authors： Liccardi G,Cazzola M,D'Amato M,D'Amato G

更新日期：2000-11-01 00:00:00

abstract：:The obstructive sleep apnoea syndrome (OSAS) is a condition causing daytime sleepiness and has been related to an increased risk for traffic accidents. However, the evidence linking severity of OSAS to a higher rate of automobile crashes is based on limited data. The aims of this study were to study the traffic accide...

journal_title：Respiratory medicine

authors： Lloberes P,Levy G,Descals C,Sampol G,Roca A,Sagales T,de la Calzada MD

更新日期：2000-10-01 00:00:00

abstract：:Bacterial colonization of the lower airways in patients with chronic bronchitis (CB) has been described mainly in patients with co-existing chronic obstructive pulmonary disease (COPD). Although smoking has been identified as a risk factor for bacterial colonization it is not known whether asymptomatic smokers (AS) ca...

journal_title：Respiratory medicine

authors： Qvarfordt I,Riise GC,Andersson BA,Larsson S

更新日期：2000-09-01 00:00:00